Last update
5/17/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.3
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9.5
We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
Read More
5
Limited evidence for vitamin B effectiveness
We explored various treatments for leg cramps during pregnancy, including vitamin B complex. In our findings, oral vitamin B appeared to reduce the frequency and intensity of leg cramps in a small study involving 42 women.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
Read More
Most Useful Reviews
9
Increased energy
1 people found this helpful
The best blend of B vitamins I've tried! The bottle size is good, and I feel a boost in energy when I take them. They also helped with nerve pain in my legs when paired with Benfotiamine. I'm very satisfied and will continue purchasing from IHerb!
Read More
7.5
Relieved leg cramps
I bought this for my father-in-law, who suffered from muscle cramps. Since taking it, he's greatly improved and has more energy. I recommend taking it every two days as the dosage is quite high. Good quality!
Read More
7.5
Less cramps
After experiencing leg cramps, my doctor advised me to increase my B vitamin intake. After a month of use, I've noticed a significant improvement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.3
- All Researches
9.5
We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
Read More
5
Limited evidence for vitamin B effectiveness
We explored various treatments for leg cramps during pregnancy, including vitamin B complex. In our findings, oral vitamin B appeared to reduce the frequency and intensity of leg cramps in a small study involving 42 women.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy
1 people found this helpful
The best blend of B vitamins I've tried! The bottle size is good, and I feel a boost in energy when I take them. They also helped with nerve pain in my legs when paired with Benfotiamine. I'm very satisfied and will continue purchasing from IHerb!
Read More
7.5
Relieved leg cramps
I bought this for my father-in-law, who suffered from muscle cramps. Since taking it, he's greatly improved and has more energy. I recommend taking it every two days as the dosage is quite high. Good quality!
Read More
7.5
Less cramps
After experiencing leg cramps, my doctor advised me to increase my B vitamin intake. After a month of use, I've noticed a significant improvement.
Read More
2
Not effective
I switched from another brand but haven't felt the benefits with this one. It doesn’t help with leg cramps like my previous choice did. The quality appears ordinary, and I might not repurchase.
Read More
2
Stomach issues
1 people found this helpful
I followed the advice to take this on an empty stomach, which resulted in stomach cramps. I might need to take it after meals instead, although the refreshing effect is good.
Read More
Frequently Asked Questions
7.5
Less cramps
After experiencing leg cramps, my doctor advised me to increase my B vitamin intake. After a month of use, I've noticed a significant improvement.
7.5
Relieved leg cramps
I bought this for my father-in-law, who suffered from muscle cramps. Since taking it, he's greatly improved and has more energy. I recommend taking it every two days as the dosage is quite high. Good quality!
2
Not effective
I switched from another brand but haven't felt the benefits with this one. It doesn’t help with leg cramps like my previous choice did. The quality appears ordinary, and I might not repurchase.
9
Increased energy
1 people found this helpful
The best blend of B vitamins I've tried! The bottle size is good, and I feel a boost in energy when I take them. They also helped with nerve pain in my legs when paired with Benfotiamine. I'm very satisfied and will continue purchasing from IHerb!
5
Limited evidence for vitamin B effectiveness
We explored various treatments for leg cramps during pregnancy, including vitamin B complex. In our findings, oral vitamin B appeared to reduce the frequency and intensity of leg cramps in a small study involving 42 women.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
However, the overall evidence was inconsistent and of low to very-low certainty due to design limitations and the small size of trials. Consequently, it's challenging to determine the real effectiveness and safety of vitamin B and other interventions for this common issue.
9.5
We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.
References
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. 10.1002/14651858.CD010655.pub3
- Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151. PubMed
